From bee venom to blood-brain barrier shuttles. Development of minimized apamin derivatives for brain delivery of antibodies and other cargoes
Brain delivery is a major unmet challenge because most drugs cannot cross the blood-brain barrier (BBB). Despite the restrictive nature of this barrier, brain vasculature reaches essentially every neural cell to supply it with nutrients. BBB-shuttles are molecules that take advantage of endogenous t...
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| Format: | Doctoral Thesis |
| Language: | English |
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Universitat de Barcelona
2015
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| Online Access: | http://hdl.handle.net/10803/296805 |