Determining the Conformation of Apolipoprotein E4 in Spherical High-Density Lipoprotein by Crosslinking and Fluorescence Spectroscopy
<p> Apolipoprotein E is a 299-amino acid protein with two structural domains: an NT (1-191) and C-terminal (201-299) domain that bear high affinity binding sites to the LDL receptor and lipid, respectively. In the plasma and brain, apoE associates with phospholipids and cholesterol to form dis...
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| Language: | EN |
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California State University, Long Beach
2017
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| Online Access: | http://pqdtopen.proquest.com/#viewpdf?dispub=10635137 |