Computational Identification of B Cell Clones in High-Throughput Immunoglobulin Sequencing Data
<p> Humoral immunity is driven by the expansion, somatic hypermutation, and selection of B cell clones. Each clone is the progeny of a single B cell responding to antigen. with diversified Ig receptors. The advent of next-generation sequencing technologies enables deep profiling of the Ig repe...
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| Language: | EN |
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Yale University
2017
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| Online Access: | http://pqdtopen.proquest.com/#viewpdf?dispub=10633249 |