Multifaceted Mechanism of Amicoumacin A Inhibition of Bacterial Translation

Multifaceted Mechanism of Amicoumacin A Inhibition of Bacterial Translation

Amicoumacin A (Ami) halts bacterial growth by inhibiting the ribosome during translation. The Ami binding site locates in the vicinity of the E-site codon of mRNA. However, Ami does not clash with mRNA, rather stabilizes it, which is relatively unusual and implies a unique way of translation inhibit...

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Bibliographic Details
Main Authors: Maksimova, Elena M., Vinogradova, Daria S., Osterman, Ilya A., Kasatsky, Pavel S., Nikonov, Oleg S., Milón, Pohl, Dontsova, Olga A., Sergiev, Petr V., Paleskava, Alena, Konevega, Andrey L.
Format: Article
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
amicoumacin A
antibiotic resistance
elongation factor EF-G
initiation
microscale thermophoresis
rapid kinetics
translocation
Online Access:http://hdl.handle.net/10757/655822

Internet

http://hdl.handle.net/10757/655822

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