A model system to study the effects of methylglyoxal on the yield and quality of tissue plasminogen activator produced by CHO cells
In this research, a model system for studying the effects of the toxic metabolite, methylglyoxal, was created using Chinese Hamster Ovary (CHO) cells which produce tissue plasminogen activator (t-PA). The human gene for glyoxalase I was subcloned into an inducible mammalian expression vector. This v...
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| Language: | en_US |
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2012
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| Online Access: | http://hdl.handle.net/1957/33264 |