Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

Acute bioactivation and hepatotoxicity of ketoconazole in rat and the determinant presence of flavin-containing monooxygenase (FMO) isoforms in human duodenum, jejunum, ileum, and colon microsomes and Caco-2 cell line

Two specific goals were addressed for this dissertation. First to investigate and identify the mechanistic profile of ketoconazole (KT)-induced hepatotoxicity by utilizing in vivo and in vitro approaches determining the mechanism of action for the hepatotoxicity incurred. To date, there has not been...

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Bibliographic Details
Main Author: Buckholz, Cheryl J.
Other Authors: Rodriguez, Rosita J.
Language:en_US
Published: 2012
Subjects:
Ketoconazole > Toxicity testing
Ketoconazole > Physiological effect
Ketoconazole > Mechanism of action
Monooxygenases > Physiological effect
Microsomes > Effect of chemicals on
Hepatoxicology
Intestinal absorption
Online Access:http://hdl.handle.net/1957/31055

Internet

http://hdl.handle.net/1957/31055

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