Percutaneous delivery of thalidomide and its N-alkyl analogues for treatment of rheumatoid arthritis / Colleen Goosen

Percutaneous delivery of thalidomide and its N-alkyl analogues for treatment of rheumatoid arthritis / Colleen Goosen

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Rheumatoid arthritis (RA) is a chronic inflammatory joint disease associated with high levels of tumour necrosis factor-alpha (TNF-a) in synovial fluid and synovial tissue (Saxne et al., 1989). Thalidomide is a proven inhibitor of the biological synthesis of TNF-a (Sampaio et al., 1991) and is belie...

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Bibliographic Details
Main Author: Goosen, Colleen
Published: Potchefstroom University for Christian Higher Education 2009
Subjects:
Percutaneous delivery
Thalidomide
N-alkyl analogues
Physicochemical properties
Solubility
Solubility parameter
Tumour necrosis factor-alpha
Lipophilicity
Partition coefficient
Rheumatoid arthritis
Online Access:http://hdl.handle.net/10394/1598

Internet

http://hdl.handle.net/10394/1598

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