Covalent inhibition of cyclin dependent kinase 2 (CDK2) through modification of a non-catalytic lysine side chain
Covalent Inhibitors have been used as drugs, such as aspirin. Boronic acid aldehyde warheads have been successfully used to covalently bind to lysine residues in Myeloid cell leukemia 1 (MCL-1). The covalent inhibition of MCL-1 prevents an anti-apoptosis signal. Given the success with using boronic...
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| Online Access: | http://hdl.handle.net/2047/D20317957 |