Driving the germinal center reaction toward subdominant epitopes: a potential vaccination strategy to target broadly neutralizing epitopes on HIV.
Rapidly evolving pathogens such as HIV or influenza can quickly mutate their antigenic profiles reducing the efficacy of conventional vaccination strategies. Despite this challenge, functionally required epitopes are highly conserved amongst heterologous viral strains and represent a key vulnerabili...
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| Online Access: | http://hdl.handle.net/2047/D20284697 |