Synthesis of Trypanosoma cruzi lanosterol 14α demethylase (TcCYP51) inhibitors for the treatment of Chagas disease

Synthesis of Trypanosoma cruzi lanosterol 14α demethylase (TcCYP51) inhibitors for the treatment of Chagas disease

Chagas is labeled as a neglected tropical disease (NTD) and has had no successful new drugs in the past 30 years. The current available drugs for treatment of Chagas disease, benznidazole and nifurtimox, have proven to be largely ineffective for chronic stages of the disease, and have significant si...

Full description

Bibliographic Details
Published:
Online Access:	http://hdl.handle.net/2047/d20004887

Similar Items

Male germ cell-specific knockout of cholesterogenic cytochrome P450 lanosterol 14α-demethylase (Cyp51)
by: Rok Keber, et al.
Published: (2013-06-01)

Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51.
by: Shamila S Gunatilleke, et al.
Published: (2012-01-01)

Human Lanosterol 14-Alpha Demethylase (CYP51A1) Is a Putative Target for Natural Flavonoid Luteolin 7,3′-Disulfate
by: Leonid Kaluzhskiy, et al.
Published: (2021-04-01)

Cloning and Characterization of Lanosterol 14α-Demethylase Gene from Antrodia cinnamomea
by: Chen-Hsien Lee, et al.
Published: (2007)

Design, Synthesis and Antifungal Activity Evaluation of New Thiazolin-4-ones as Potential Lanosterol 14α-Demethylase Inhibitors
by: Anca Stana, et al.
Published: (2017-01-01)

Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol.
by: SF Tuck, et al.
Published: (1991-06-01)

Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals.
by: Joel D A Tyndall, et al.
Published: (2016-01-01)

Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity
by: Caio H. Franco, et al.
Published: (2020-08-01)

Synthesis, Molecular Docking Studies, and Antifungal Activity Evaluation of New Benzimidazole-Triazoles as Potential Lanosterol 14α-Demethylase Inhibitors
by: Nafiz Öncü Can, et al.
Published: (2017-01-01)

Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Δ7-24, 25-dihydrolanosterol
by: Tatiana Y. Hargrove, et al.
Published: (2012-02-01)

Estudo in silico de inibidores de lanosterol 14alfa-desmetilase de Trypanosoma cruzi
by: Melo, Francielle Martins de
Published: (2017)

An Erg11 lanosterol 14-α-demethylase-Arv1 complex is required for Candida albicans virulence.
by: Michelle L Villasmil, et al.
Published: (2020-01-01)

Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.
by: Chiung-Kuang Chen, et al.
Published: (2009-01-01)

Point Mutations in the 14-α Sterol Demethylase Cyp51A or Cyp51C Could Contribute to Azole Resistance in <i>Aspergillus flavus</i>
by: Jose Lucio, et al.
Published: (2020-10-01)

Fatal acute Chagas disease by Trypanosoma cruzi DTU TcI, Ecuador
by: Manuel Calvopina, et al.
Published: (2020-02-01)

Data on molecular docking of tautomers and enantiomers of ATTAF-1 and ATTAF-2 selectivty to the human/fungal lanosterol-14α-demethylase
by: Hamid Irannejad, et al.
Published: (2020-08-01)

Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease.
by: Jennifer Riley, et al.
Published: (2015-09-01)

Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole.
by: Chiung-Kuang Chen, et al.
Published: (2010-04-01)

The stepwise selection for ketoconazole resistance induces upregulation of C14-demethylase (CYP51) in Leishmania amazonensis
by: Valter Viana Andrade-Neto, et al.
Published: (2012-05-01)

Analysis of the ergosterol biosynthesis pathway cloning, molecular characterization and phylogeny of lanosterol 14α-demethylase (ERG11) gene of Moniliophthora perniciosa
by: Geruza de Oliveira Ceita, et al.
Published: (2014-12-01)

Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase
by: H. James Harwood, Jr., et al.
Published: (2005-03-01)

In silico prediction of ATTAF-1 and ATTAF-2 selectivity towards human/fungal lanosterol 14α-demethylase using molecular dynamic simulation and docking approaches
by: Hamid Irannejad, et al.
Published: (2020-01-01)

Pfcyp51 exclusively determines reduced sensitivity to 14α-demethylase inhibitor fungicides in the banana black Sigatoka pathogen Pseudocercospora fijiensis.
by: Pablo Chong, et al.
Published: (2019-01-01)

Virtual Screening Based on QSAR and Molecular Docking of Possible Inhibitors Targeting Chagas CYP51
by: J. Cotuá, et al.
Published: (2021-01-01)

Performance of TcI/TcVI/TcII Chagas-Flow ATE-IgG2a for universal and genotype-specific serodiagnosis of Trypanosoma cruzi infection.
by: Glaucia Diniz Alessio, et al.
Published: (2017-03-01)

Oxidation of Isodrimeninol with PCC Yields Drimane Derivatives with Activity against <i>Candida</i> Yeast by Inhibition of Lanosterol 14-Alpha Demethylase
by: Victor Marin, et al.
Published: (2020-07-01)

Trypanosoma cruzi 80 kDa prolyl oligopeptidase (Tc80) as a novel immunogen for Chagas disease vaccine.
by: Augusto E Bivona, et al.
Published: (2018-03-01)

Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment
by: Elena Aguilera, et al.

Analysis of ergosterol and gene expression profiles of sterol Δ5,6-desaturase (ERG3) and lanosterol 14α-demethylase (ERG11) in Candida albicans treated with carvacrol
by: Fahimeh Alizadeh, et al.
Published: (2018-04-01)

A Nano-MgO and Ionic Liquid-Catalyzed 'Green' Synthesis Protocol for the Development of Adamantyl-Imidazolo-Thiadiazoles as Anti-Tuberculosis Agents Targeting Sterol 14α-Demethylase (CYP51).
by: Sebastian Anusha, et al.
Published: (2015-01-01)

Demethylase Inhibitor Fungicide Resistance in Pyrenophora teres f. sp. teres Associated with Target Site Modification and Inducible Overexpression of Cyp51
by: Wesley John Mair, et al.
Published: (2016-08-01)

Meiotic sex in Chagas disease parasite Trypanosoma cruzi
by: Philipp Schwabl, et al.
Published: (2019-09-01)

Differential expression of proteins in genetically distinct Trypanosoma cruzi samples (TcI and TcII DTUs) isolated from chronic Chagas disease cardiac patients
by: Maykon Tavares de Oliveira, et al.
Published: (2018-11-01)

Mechanistic studies of lanosterol 14 alpha-methyl demethylase: substrate requirements for the component reactions catalyzed by a single cytochrome P-450 isozyme.
by: R T Fischer, et al.
Published: (1989-10-01)

Synthesis and Biological Activity of Sterol 14α-Demethylase and Sterol C24-Methyltransferase Inhibitors
by: David J. Leaver
Published: (2018-07-01)

Association between Trypanosoma cruzi DTU TcII and chronic Chagas disease clinical presentation and outcome in an urban cohort in Brazil.
by: Marco Antonio Prates Nielebock, et al.
Published: (2020-01-01)

The Role of the Trypanosoma cruzi TcNRBD1 Protein in Translation.
by: Camila Oliveira, et al.
Published: (2016-01-01)

The Trypanosoma cruzi Protein TcHTE Is Critical for Heme Uptake.
by: Marcelo L Merli, et al.
Published: (2016-01-01)

CARACTERIZAÇÃO DE TcRBSR1 EM Trypanosoma cruzi
by: MALGARIN, JULIANE SOLDI
Published: (2016)

Indomethacin-Amides As Molecular Scaffolds To Investigate The Structure and Function of Cyclooxygenases, Thromboxane Synthase, and Sterol 14-alpha Demethylase From Trypanosoma Cruzi
by: Konkle, Mary Elizabeth
Published: (2008)