Evaluation of mucin glycosylation as a barrier to drug uptake: a quantitative approach.
Mucins are heavily glycosylated glycoproteins that form a thick layer (glycocalyx) through which all molecules must diffuse to gain access to intracellular targets. They are overexpressed in cancerous conditions and have been implicated in invasion and metastasis of variety of tumors. Over 85% of hu...
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| Online Access: | http://hdl.handle.net/2047/d20000236 |