Structure-function studies of agonist binding to the muscle-type nicotinic acetylcholine receptor and the development of a trifunctional non-competitive antagonist suitable for activity-dependent profiling

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2008. === Vita. === Includes bibliographical references. === The muscle-type nicotinic acetylcholine receptor (AChR) is a ligand-gated ion channel required for fast synaptic transmission at the neuromuscular junction. It is...

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Bibliographic Details
Main Author: Tantama, Mathew C
Other Authors: Stuart S. Licht.
Format: Others
Language:English
Published: Massachusetts Institute of Technology 2009
Subjects:
Online Access:http://hdl.handle.net/1721.1/46035