The role of parasite-derived arginase in murine Leishmania major

The outcome of infection with Leishmania major depends in part on the balance between arginase and inducible nitric oxide synthase in macrophages. These enzymes compete for the substrate L-arginine. Leishmania major also encodes an arginase gene but, the role of this parasite-derived enzyme in inf...

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Bibliographic Details
Main Author: Muleme, Helen
Other Authors: Uzonna, Jude (Immunology)
Language:en_US
Published: 2010
Subjects:
Online Access:http://hdl.handle.net/1993/3920