Thymidylate synthesis and folate metabolism by the obligate intracellular parasite Chlamydiae : metabolic studies and molecular cloning
Since host cell-derived thymidine is not incorporated into Chlamydia trachomatis DNA, we hypothesized that chlamydiae must synthesize dTMF de novo for DNA replication. The only known enzyme performing de novo dTMP synthesis is thymidylate synthase (TS). The goals of this thesis were to provide bi...
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2013
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| Online Access: | http://hdl.handle.net/1993/22224 |