Bypassing immunization in an attempt to develop beta 1 specific monoclonal human antibodies from semi-synthetic repertoires
Immune selection can be mimiced 'in vitro' by displaying antibody repertoires on the surface of a filamentous bacteriophage and selecting phage by binding to antigen. The development of recombinant DNA methods and the knowledge that antibody fragments could be functionally expressed and a...
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| Language: | en_US |
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2007
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| Online Access: | http://hdl.handle.net/1993/2221 |