The Role of Cysteine 230 and Lysine 238 of Biotin Carboxylase in the Deprotonation of Biotin and Synthesis of a Bisubstrate Analog Inhibitor of Carboxyltransferase
Acetyl-CoA carboxylase catalyzes the first step in the synthesis of fatty acids. The Escherichia coli form of the enzyme consists of a biotin carboxylase protein, a biotin carboxyl carrier protein, and a carboxyltransferase protein. This enzyme uses the cofactor biotin as a carboxyl carrier. In orde...
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| Format: | Others |
| Language: | en |
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LSU
2002
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| Online Access: | http://etd.lsu.edu/docs/available/etd-0416102-152847/ |