Regulation of the initiation of DNA replication: Interplay between DNA topology and chromatin structure
DNA replication initiates at replication origins and involves the ordered assembly of a pre-Replicative Complex (pre-RC), consisting of the ORC1-6, Cdc6, Cdt1 and MCM2-7 proteins. The Ku heterodimer (Ku70/Ku80) was previously implicated in the pre-RC assembly but its mechanism of action is yet unkno...
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| Format: | Others |
| Language: | en |
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McGill University
2009
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40783 |