Synthesis and gene silencing activity of ribonucleic acid duplexes containing 3'-deoxy-3'-thiothymidine

Synthesis and gene silencing activity of ribonucleic acid duplexes containing 3'-deoxy-3'-thiothymidine

This thesis reports the first synthesis and biophysical characterization of oligoribonucleotides (RNA) containing 3'-deoxy-3'-thiothymidine (3'-S-dT) units. Optimized conditions for incorporating 3'-S-dT into 21-nt RNA strands is also...

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Bibliographic Details
Main Author: Isaac, Siara
Other Authors: Masad J Damha (Internal/Supervisor)
Format: Others
Language:en
Published: McGill University 2009
Subjects:
Chemistry - Organic
Online Access:http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32408

Internet

http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32408

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