Bioisosteres of phosphate and pyrophosphate ligands as inhibitors of therapeutic targets
Part IHuman farnesyl pyrophosphate synthase (hFPPS) represents a critical enzyme which controls the first branch point of mevalonate pathway. It catalyzes the consecutive condensations of dimethylallyl pyrophosphate (DMAPP) with two molecules of isopentenyl pyrophosphate (IPP) to generate farnesyl p...
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| Format: | Others |
| Language: | en |
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McGill University
2014
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123221 |