Dual inhibition of Ataxia-telangiectasia and Rad3-related (ATR) and Poly-ADP polymerase (PAPR) pathways enhances Topoisomerase l cytotoxicity in colon cancer cell lines:pre- clinical assessment of pathway-specific novel therapeutics
Manipulating the DNA repair mechanisms involved in the repair of Topoisomerase-I (Top I) mediated DNA damage may enhance the therapeutic benefits of Top I poisons. Poly-ADP ribose polymerase (PARP) inhibitors can increase the cytotoxicity of several anticancer agents by inhibiting various DNA repair...
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| Format: | Others |
| Language: | en |
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McGill University
2014
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123053 |