Allele-specific analyses of gene expression and chromatin state yield new insights into cis-regulatory mechanisms and their role in complex disease

Cis-regulatory variants are predicted to mediate the majority of the known common genetic associations to complex disease, yet the specific causal variants and the corresponding cis-regulatory mechanisms have thus far been poorly characterized. We attempted to address this by using allele-specific a...

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Bibliographic Details
Main Author: Light, Nicholas
Other Authors: Tomi Markku Pastinen (Internal/Supervisor)
Format: Others
Language:en
Published: McGill University 2014
Subjects:
Online Access:http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121378

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