The HIV-1 protein Nef disrupts T cell receptor signalling and thymic function
The HIV-1 Nef protein is a virulence factor and major determinant of pathogenicity of the virus. Nef impairs T cell function by uncoupling TcR signaling from antigen stimulation and by down regulating CD4 on the cell surface. In Nef infected thymocytes, the activity of intracellular T signaling mole...
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| Format: | Others |
| Language: | en |
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McGill University
2013
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119458 |