Structure-function analysis of AID reveals intramolecular catalytic inhibition and a novel functional domain required for targeting to chromatin
The B-cell specific enzyme Activation-induced deaminase (AID) is responsible for the diversification of rearranged antibody genes in activated B cells during humoral immune responses. AID deaminates dC to dU at the Immunoglobulin (Ig) loci and the uracil thereby introduced is processed in an error-p...
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| Format: | Others |
| Language: | en |
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McGill University
2013
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114341 |