The mitochondrial processing peptidase regulates PINK1 processing, import, and Parkin recruitment
Mutations in PTEN-induced kinase 1 (PINK1) cause recessively-inherited Parkinson's disease (PD), a neurodegenerative disorder thought to involve mitochondrial defects. The PINK1 protein is imported into healthy mitochondria and rapidly degraded, but accumulates at the surface of mitochondria fo...
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| Format: | Others |
| Language: | en |
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McGill University
2012
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106415 |