Stereoselective formation of all carbon quaternary centers: synthesis of alpha,alpha-disubstituted beta-amino carbonyl compounds via the Mannich reaction and total synthesis of (-)-puraquinonic acid
A bicyclic thioglycolate lactam chiral auxiliary was previously developed in our group for the asymmetric formation of quaternary carbon stereocenters via enolate alkylation. This method is notable for the stereocontrolled generation of alpha, alpha-disubstituted amide enolates, without reliance on...
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| Format: | Others |
| Language: | en |
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McGill University
2011
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104585 |