Allergen-induced growth of airway smooth muscle: structure-function relations and modulation by corticosteroids and the epidermal growth factor receptor

In experimental asthma, allergen challenges cause airway structural changes, termed remodeling, including an increase in smooth muscle (SM) mass and goblet cell metaplasia. These changes are substantially mediated via the epidermal growth factor receptor (EGFR) and its axis of ligands. The causal...

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Bibliographic Details
Main Author: Siddiqui, Sana
Other Authors: James G Martin (Supervisor)
Format: Others
Language:en
Published: McGill University 2011
Subjects:
Online Access:http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104472