The effect of namH disruption in Mycobacterium tuberculosis on the pathogenesis of experimental tuberculosis
Peptidoglycan-derived muramyl dipeptide (MDP) activates the host immune response through the NOD2 receptor. Mycobacteria produce an unusual, glycolylated form of MDP, through the action of the enzyme N-acetyl muramic acid hydroxylase (NamH), that is more potent and more efficacious at inducing NOD2...
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| Format: | Others |
| Language: | en |
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McGill University
2011
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| Online Access: | http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103751 |