Enantioselective Rh(I)-Catalyzed Conjugate Alkynylation of 5-Benzylidene Meldrum’s Acid with TMS-acetylene
The Rh-catalyzed conjugate addition of TMS-acetylene to alkylidene Meldrum’s acids was developed. Exceptional ee’s and yields were attained using chiral 3,5-Xylyl-BIPHEP ligand. The scope of the reaction was also shown to be very broad with functionalities including phenol, silyl ether, and boronate...
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| Language: | en |
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2009
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| Online Access: | http://hdl.handle.net/10012/4629 |