Requirements for Notch Signaling in Positive Selection and Effector Function of CD8 T Cells
The generation of the cytotoxic CD8 T cell response is dependent on the functional outcomes imposed by the intrathymic constraints of differentiation and self-tolerance. Although thymic function can be partly replicated in vitro using OP9-DL1 cell cultures to yield CD8 αβ T cell receptor (TCR)-beari...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/43384 |