The Role of Mechanical Stress in Regulating Integrin Recruitment to Latent TGF-β1
Fibrosis is characterized by excessive extracellular matrix (ECM) production and contraction of myofibroblasts that differentiate from fibroblasts under the action of pro-fibrotic cytokine TGF-β1 and mechanical stress. Myofibroblasts liberate active TGF-β1 by integrin-mediated pulling on the latency...
| Main Author: | |
|---|---|
| Other Authors: | |
| Language: | en_ca |
| Published: |
2012
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/1807/33280 |