V-ATPase a3-d2 and a3-B2 Subunit Interaction in Osteoclasts are Viable Targets for Anti-resorptive Therapeutics
For bone resorption, vacuolar-type H+-ATPases (V-ATPases) on the plasma membranes of osteoclasts acidifies the extracellular millieu adjacent to the bone surface. The V-ATPase a3 and d2 subunits are enriched in osteoclasts. B2 subunit is also expressed on the osteoclast plasma membrane. Disruption...
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| Language: | en_ca |
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2012
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| Online Access: | http://hdl.handle.net/1807/32236 |