Molecular Rationale and Determinants of Sensitivity for Statin-Induced Apoptosis of Human Tumour Cells

Molecular Rationale and Determinants of Sensitivity for Statin-Induced Apoptosis of Human Tumour Cells

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The statin family of hydroxymethylglutaryl coenzyme A reductase (HMGCR) inhibitors, used to control hypercholesterolemia, triggers apoptosis of various human tumour cells. HMGCR is the rate-limiting enzyme of the mevalonate (MVA) pathway, a fundamental metabolic pathway required for the generation...

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Bibliographic Details
Main Author: Clendening, James William
Other Authors: Penn, Linda Z.
Language:en_ca
Published: 2010
Subjects:
statins
anti-cancer therapeutics
HMGCR
HMG-CoA reductase
ovarian cancer
multiple myeloma
apoptosis
drug sensitivity
drug resistance
mevalonate
transformation
tumour metabolism
0307
0992
Online Access:http://hdl.handle.net/1807/26452

Internet

http://hdl.handle.net/1807/26452

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