Multigene Therapy by Ultrasound-mediated Plasmid Delivery: Temporally Separated Delivery of Vascular Endothelial Growth Factor and Angiopoietin-1 Promotes Sustained Angiogenesis in Chronically Ischemic Skeletal Muscle
Endogenously, VEGF initiates angiogenesis, then later Angiopoietin (Ang)-1 matures vessels. We hypothesized that multigene therapy of VEGF before Ang1 to ischemic hindlimb tissue would result in persistent angiogenesis. At 2, 4 and 8 wks after inducing ischemia, blood flow was assessed by contrast-e...
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| Language: | en_ca |
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2010
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| Online Access: | http://hdl.handle.net/1807/25804 |