Role of the Tumor Suppressor ARF and the p53-pathway in Retinoblastoma Development
Retinoblastoma development is a multistep process, and inactivation of the RB1 gene is not sufficient for tumorigenesis. Previous studies suggest that the p53-tumor suppressor is inactivated due to overexpression of p53-antagonists MDM4 and MDM2. This thesis evaluates the importance of ARF, a p53-ac...
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| Language: | en_ca |
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2009
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| Online Access: | http://hdl.handle.net/1807/18965 |