ICAM-1 as a Novel Binding Partner for LPS to Mediate TLR4-Independent Cell Activation
Introduction: The mechanism of cell activation by LPS in the absence of surface Toll-like receptor 4 (TLR4) is unclear. We hypothesize that ICAM-1 binds LPS on the cell surface, mediating cell activation independent of TLR4. Methods: The interaction between murine ICAM-1 and LPS was measured in a b...
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| Language: | en_ca |
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2009
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| Online Access: | http://hdl.handle.net/1807/17702 |