Ectopic Notch Activation in Developing Podocytes Impairs Slit Diaphragm Formation and Induces Abnormal Podocyte Differentiation

Ectopic Notch Activation in Developing Podocytes Impairs Slit Diaphragm Formation and Induces Abnormal Podocyte Differentiation

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Podocytes are terminally differentiated epithelial cells which regulate glomerular permselectivity by their cell-cell junctions, known as slit diaphragms (SD). Notch signaling regulates podocyte cell fate specification and downregulation of Notch targets occurs with terminal podocyte differentiation...

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Bibliographic Details
Main Author: Waters, Aoife
Other Authors: Piscione, Tino D.
Language:en_US
Published: 2009
Subjects:
Notch
glomerulosclerosis
0714
Online Access:http://hdl.handle.net/1807/17450

Internet

http://hdl.handle.net/1807/17450

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