Characterization of cAMP-Specific Phosphodiesterase-4 (R)-[11C]Rolipram Small Animal Positron Emission Tomography and Application in a Streptozotocin-Induced Model of Hyperglycemia
Elevated sympathetic nervous system (SNS) tone contributes to excess cardiac mortality associated with type 2 diabetes mellitus (T2DM). Chronic SNS stimulation has detrimental effects to the heart, in particular, with its cell signaling abilities. (R)-[11C]Rolipram small animal positron emission tom...
| Main Author: | |
|---|---|
| Language: | en |
| Published: |
2011
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10393/19877 |