The Impact of Chlorine Substituents on the Regioselectivity of Pd(0)-catalyzed Direct Arylation of Heteroaromatics
The regioselectivity in Pd(0)-catalyzed direct arylation of pyrrole, thiophene, and indole can be improved by blocking some of the reactive sites with a chloride group, leading to increased yields of the desired regioisomers. Competition experiments and computational studies show that the blocking...
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| Language: | en |
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2011
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| Online Access: | http://hdl.handle.net/10393/19788 |