Probing the Stereospecificity and Chemospecificity of Polyketide Thioesterases
Macrocyclization is a synthetically challenging step in the total synthesis of natural products. The success of chemical approaches such as the Corey-Nicolaou, Yamaguchi and Keck macrolactonization is heavily based on the confirmation and stereochemistry of the substrate. While there have been som...
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| Language: | en |
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2014
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| Online Access: | http://hdl.handle.net/10393/31034 |