Inducing Cellular Senescence in Cancer

Cellular senescence is a permanent cell cycle arrest that is induced as a response to cellular stress. Replicative senescence is a well-described mechanism that limits the replicative capacity of cells and must be overcome by cancer cells. Oncogene-induced senescence (OIS) is a form of premature sen...

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Bibliographic Details
Main Author: Restall, Ian J.
Language:en
Published: 2013
Subjects:
p21
Online Access:http://hdl.handle.net/10393/23691