A Gain of Function Variant of the Mitochondrial Matrix Protease SPG7 Is Associated with Increased Risk of Coronary Artery Disease

A Gain of Function Variant of the Mitochondrial Matrix Protease SPG7 Is Associated with Increased Risk of Coronary Artery Disease

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Genome-wide association studies (GWAS) have identified up to 30 loci that associate with increased risk of coronary artery disease or myocardial infarction. Here, I tested the function of one locus that changed the amino acid sequence of a mitochondrial matrix protease called paraplegin (SPG7) that...

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Bibliographic Details
Main Author: Almontashiri, Naif
Language:en
Published: 2012
Subjects:
CAD
SPG7
ROS
Cell proliferation
Online Access:http://hdl.handle.net/10393/22665

Internet

http://hdl.handle.net/10393/22665

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