Investigating Organic Nitrate Tolerance and Alzheimer's Disease: Roles for Aldehyde Dehydrogenase 2 and 4-Hydroxynonenal
Organic nitrates, such as glyceryl trinitrate (GTN), have been used clinically for more than a century. However optimal nitrate therapy is hindered by the development of tolerance, which is associated with a desensitized response to GTN, oxidative stress, and the inactivation of aldehyde dehydrogena...
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| Language: | en en |
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2013
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| Online Access: | http://hdl.handle.net/1974/8059 |