Structural and functional characterization of E2A:KIX interactions in leukemia
The E2A proteins are transcription factors critical for B-lymphopoiesis. A chromosomal translocation involving the E2A gene promotes acute lymphoblastic leukemia (ALL) through expression of the oncoprotein E2A-PBX1. Two activation domains of E2A-PBX1, AD1 and AD2, have been implicated in transcripti...
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| Language: | en en |
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2012
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| Online Access: | http://hdl.handle.net/1974/7469 |