Characterization of a Newly Synthesized Cysteinyl Leukotriene 2 Receptor Selective Antagonist Using Cell Based β-arrestin and Vascular Ear Permeability Assays in Mice

Characterization of a Newly Synthesized Cysteinyl Leukotriene 2 Receptor Selective Antagonist Using Cell Based β-arrestin and Vascular Ear Permeability Assays in Mice

(hCysLT2R) based on a β-galactosidase complementation system. The EC50 values for LTC4 and LTD4 are consistent with previous literature values determined based on radio-labelling affinity assays for hCysLT2R. Activity of a synthetic analogue of LTC4, N-Methyl LTC4 (NMLTC4), gave an EC50 value of 8.5...

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Bibliographic Details
Main Author: YAN, DONG
Other Authors: Queen's University (Kingston, Ont.). Theses (Queen's University (Kingston, Ont.))
Language:en
en
Published: 2011
Subjects:
Biochemistry
Fatty Acid Metabolites
Online Access:http://hdl.handle.net/1974/6597

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