Characterization of a Newly Synthesized Cysteinyl Leukotriene 2 Receptor Selective Antagonist Using Cell Based β-arrestin and Vascular Ear Permeability Assays in Mice
(hCysLT2R) based on a β-galactosidase complementation system. The EC50 values for LTC4 and LTD4 are consistent with previous literature values determined based on radio-labelling affinity assays for hCysLT2R. Activity of a synthetic analogue of LTC4, N-Methyl LTC4 (NMLTC4), gave an EC50 value of 8.5...
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| Language: | en en |
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2011
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| Online Access: | http://hdl.handle.net/1974/6597 |