Itch E3 ubiquitin ligase regulates LATS1 tumour suppressor stability
The Large Tumor Suppressor 1 (LATS1) is a serine/threonine kinase and tumor suppressor found down-regulated in a broad spectrum of human cancers. It is a central player of the emerging Hippo-LATS tumour suppressor pathway, which plays important roles in cell proliferation, apoptosis, and stem cell d...
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| Language: | en en |
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2011
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| Online Access: | http://hdl.handle.net/1974/6424 |