RECIPROCAL REGULATION OF E-CADHERIN AND SHP2 BY THE EXTRACELLULAR CA2+-SENSING RECEPTOR IN COLONIC EPITHELIAL ADENOCARCINOMA CELLS
Colon cancer is characterized by the progressive loss of E-cadherin, a Ca2+-dependent adherens junction component and epithelial marker. Furthermore, inhibition of the phosphatase SHP2, essential in the cell survival signaling via the epidermal growth factor receptor pathway, has been shown to upre...
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| Format: | Others |
| Language: | en en |
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2009
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| Online Access: | http://hdl.handle.net/1974/1943 |