Increased VIP Receptor Expression Mediates CFTR Membrane Localization in Response to VIP Treatment in VIP Knockout Mice
Cystic Fibrosis (CF) is caused by mutations in CFTR, a protein for chloride efflux in epithelial cells. VIP is a peptide that activates CFTR and improves membrane stability; VIP has 3 receptors VPAC1, VPAC2 and PAC1 that can cause CFTR phosphorylation. VIP-knockout (VIPKO) mice experience inflammati...
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| Language: | en |
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2011
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| Online Access: | http://hdl.handle.net/10222/14231 |