Analysis of Saccharomyces cerevisiae genetic background and mitochondrial DNA polymerase variants on maintenance of the mitochondrial genome.
The contribution of yeast strain background, specifically auxotrophic markers, to stability and fidelity of mtDNA replication was investigated. In summary, the ade2, his3delta200, and hap1 mutations have complex effects on mitochondrial functions, the severity of which appears to depend on other com...
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| Language: | en_US |
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2008
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| Online Access: | http://hdl.handle.net/1993/3064 |