Induction of DT-diaphorase by 1,2-dithiole-3-thiones and the enhancement of antitumour activity of bioreductive agents
DT-diaphorase is a two-electron reducing enzyme that is an important activator of bioreductive antitumour agents, such as mitomycin C and EO9. DT-diaphorase is highly inducible by a wide variety of compounds, including 1,2-dithiole-3-thiones (D3T's), and these compounds could be used to enhance...
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| Language: | en_US |
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2007
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| Online Access: | http://hdl.handle.net/1993/1007 |